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New treatment and possible vaccine for multi drug-resistant TB

Current methods of treatment are ineffective against multi-drug-resistant tuberculosis. Photo: David Gough/IRIN.Irish researchers working on tuberculosis have developed treatment strategies which could be effective against the multi-drug-resistant strain of the disease.

Head of the TB Immunology Lab in Trinity College Dublin, Dr Joe Keane said significant discoveries have been made by the centre.

“We are punching way above our weight.” he said. “Scientific funding enables us not just to do basic research but also makes possible clinical results that will impact policy now and improve general health.”

A partnership between the lab, St James’ Hospital and the Royal College of Surgeons has resulted in the development of inhalable treatments which could allow for treatment of MDR-TB.

This strain is causing the most concern among experts in Ireland because, Dr Keane said, present methods of treatment – a course of antibiotics for six or nine months – are ineffective.

Further study carried out by Dr Ryan and Dr O’Sullivan has revealed the possibility of using cells found in the lung – dendritic cells – as a basis for a vaccine according to Dr Keane.

“They noticed that even though these cells die after infection with TB, they contribute, in death, to improving the body’s immunity against the disease. This could help to generate a vaccine, because there is no really effective vaccine for TB in the world today,” he said.

€2m prize for breakthrough in vaccine storage or transport welcomed

Porter Mohammed Abu Taher transports cold boxes of measles vaccine to a distribution point at Boalkhali Subdistrict Health Complex in Chittagong District, Bangladesh. From here, health workers will transport the vaccines to schools and outreach centres, keeping them at a constant, low temperature, a process known as maintaining the ‘cold chain’. Many existing vaccines are difficult to transport and expensive to store, according to Dr Anne Moore of University College Cork. Photo: UNICEF/Shehzad Noorani.A new prize-fund of two million euro for scientists working on vaccines has been welcomed by a leading Irish researcher.

Dr Anne Moore, pharmacology lecturer and researcher at University College Cork (UCC), said the European Commission prize is an exciting development.

“This will be of great benefit and will make an impact on my work and that going on around Europe,” she said. “It is a more simplified application process than the normal EU grant application, less cumbersome and more focused.”

The prize targets research into methods of stabilising vaccines for diseases including TB and malaria. According to Dr Moore many of the existing vaccines are difficult to transport, expensive to store and often destablise in the intense heat of regions like Sub-Saharan Africa where they are most needed.

The scientist, who has also worked with the University of Michigan and Oxford University, said research into these challenges is being carried out by everyone from SMEs to large pharmaceutical companies.

The UCC department is at present developing an “Immunopatch”. Dr Moore said this means a small patch with tiny solid needles made of vaccine which can be stuck on someone’s skin to directly impart the vaccine to a sick person.

USD800m public-private initiative against neglected tropical diseases launched

Armed Forces Pest Management Board.[LONDON] A major public-private initiative to control or eliminate at least ten neglected tropical diseases (NTDs) by 2020 was unveiled in London Monday (30 January) alongside a WHO roadmap on how to do it.

Non-governmental organisations, aid donors and 13 global drug companies came together, in the largest coordinated effort on NTDs, to back the 'London Declaration on Neglected Tropical Diseases'.

Almost US$800 million was pledged and new research initiatives were launched at what Margaret Chan, WHO secretary-general, called the "most coordinated initiative" in her 30 years in public health.

The declaration agreed to "sustain, expand and extend" drug supplies to help eradicate Guinea worm disease; to eliminate lymphatic filariasis, leprosy, sleeping sickness and blinding trachoma; and to control schistosomiasis, soil-transmitted helminthes, Chagas disease, visceral leishmaniasis and river blindness (onchocerciasis).

These ten diseases are some of the 17 NTDs that affect more than a billion people globally.

Irish medical charity hopes to put itself out of business

Registrar in emergency medicine, Dr Eoin Fogarty (third from left), with staff from Muhumbili National hospital in Dar es Salam, Tanzania. Photograph: Global Emergency Care Skills (GECS).A wheelchair made from a deck-chair, cardboard plaster casts and sedatives only available to wealthy patients. These are just some of the challenges for surgeons working in East, Central and Southern Africa according to Dr Jean O’ Sullivan.

Dr. O’Sullivan, consultant in accident and emergency medicine at Tallaght hospital in Dublin, says a road accident in Ireland might be attended by 15 medical staff where only one person could be available in rural Kenya.

“You can have one person dealing with an overwhelming situation. So something we would think is easy to fix like a ruptured liver or fracture becomes impossible. There are so few doctors an intern could be the only doctor in a country hospital,” she says.

Responding to the need for more staff, Dr O’Sullivan founded Global Emergency Care Skills (GECS) to provide training for doctors and nurses in developing countries in 2008.

Ending female genital mutilation: it takes a village

A young girl in Garissa, Northeastern Kenya. She is one of 120 girls staying at a sanctuary for girls at risk of female genital mutilation/cutting (FGM/C). The centre is run by a local NGO, WOMANKIND Kenya. Photo: Ann Weru / IRIN.Girls or their families that refuse circumcision against the will of their villages may become social outcasts. But using a new community-based approach, two UN agencies hope that female genital mutilation can be eliminated within a generation. UNFPA and UNICEF are using a human rights-based approach to encourage communities to act collectively. This approach has led some 6,000 communities across Africa to abandon the practice, usually through a public declaration.

Female genital mutilation/cutting has devastating short- and long-term impacts on the lives of women and girls, say the UN. It can cause severe bleeding and problems urinating, psychological disorders and even death (WHO).

The impact even extends to the next generation. Death rates among babies during and immediately after birth are higher for those born to mothers who have undergone the practice, by an estimated one to two babies per 100 deliveries.

More than 90 million African women and girls have undergone female genital mutilation - 100-140 million worldwide - according to World Health Organisation (WHO) estimates. In Africa, about 3 million girls are at risk annually. It is mostly carried out on girls aged 0-15.

Malaria death toll much greater than thought - strong link to bacterial infections found

Invasive bacterial disease - a major cause of childhood death and illness - is six to seven times more likely in children with malaria. Photo: Flickr/US Army Africa.Reducing the incidence of malaria could also drastically reduce the number of deaths from bacterial infections among children in Africa, a study has found.

"Children who are protected from malaria are less likely to catch bacterial infections. It therefore means that controlling malaria will give an additional benefit," Anthony Scott, the lead author and a researcher at the KEMRI-Wellcome Trust Research Programme, in Kenya, told SciDev.Net

Invasive bacterial diseases, such as pneumonia, meningitis and sepsis, are a major cause of illness and death among children in Africa, with mortality in Kenya as high as 22 per cent of those infected.

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