Irish researchers working on tuberculosis have developed treatment strategies which could be effective against the multi-drug-resistant strain of the disease.
Head of the TB Immunology Lab in Trinity College Dublin, Dr Joe Keane said significant discoveries have been made by the centre.
“We are punching way above our weight.” he said. “Scientific funding enables us not just to do basic research but also makes possible clinical results that will impact policy now and improve general health.”
A partnership between the lab, St James’ Hospital and the Royal College of Surgeons has resulted in the development of inhalable treatments which could allow for treatment of MDR-TB.
This strain is causing the most concern among experts in Ireland because, Dr Keane said, present methods of treatment – a course of antibiotics for six or nine months – are ineffective.
Further study carried out by Dr Ryan and Dr O’Sullivan has revealed the possibility of using cells found in the lung – dendritic cells – as a basis for a vaccine according to Dr Keane.
“They noticed that even though these cells die after infection with TB, they contribute, in death, to improving the body’s immunity against the disease. This could help to generate a vaccine, because there is no really effective vaccine for TB in the world today,” he said.